Synthesis, structure and anticancer activities of Zn(II), Cd(II) complexes with 5,7-dichloro-8-hydroxyquinoline-2-carboxaldehyde-4-methyl-3-thiosemicarbazone

Abstract

Two new complexes [Zn(QMS)] and [Cd(QMS)] were synthesized by reaction between MCl₂(M = Zn, Cd) with  5,7-dichloro-8-hydroxyquinoline-2-carboxaldehyde-4-methyl-3-thiosemicarbazone (H₂QMS). Their structures were determined by ESI-MS, IR and ¹H NMR spectroscopies. The results showed that in these complexes the ratio of M(II) : H₂QMS ligand is  1 : 1, M(II) is bound to H₂QMS ligand through O, N_quinoline, N_{thiosemicarbazide} and S atoms. The complexes were tested for cell in vitro cytotoxicity on human cancer cells including KB, Hep-G2, LU and MCF-7. The results showed that ZnQMS complex exhibits high antitumor activities on KB, Hep-G2, Lu cancer cell lines with IC₅₀ values 9,41; 5,53 and 6,73 μM respectively. CdQMS complex gives a high activity against on LU cancer cell line with IC₅₀ value 4,54 μM.