Research on efficient synthetic method of β- and δ-carbolines using a Copper catalyst

Phuc Van Ban, Quan Minh Nguyen, Hien Nguyen, Tien Quyet Nguyen, Nga Thi Thanh Truong, Tuan Ngoc Nguyen, An Quang Nguyen, Hanh Hong Cu, Tuan Dang Thanh, Hung Quang Hung

Abstract


Methodology for synthesizing of β- and δ-carboline via two steps reaction from 2,3-dibromopyridine and 3,4-dibromopyridine. The intermediate was prepared from the substrate with o-bromophenylboronic acid via site-selective Suzuki-Myaura reaction, then, the final products were obtained by double C-N coupling via the Ulmann reaction of the intermediate with the corresponding amine with copper catalyst.

Keywords


C-N coupling; Ulmann reaction; β-carboline; δ-carboline; copper catalysis

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References


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DOI: https://doi.org/10.51316/jca.2022.069

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